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The incidence and prognostic significance of extracapsular spread (ECS) of tumor in cervical lymphatics was investigated. The surgical specimens from 349 patients treated for squamous cell carcinoma by radical neck dissection between 1978 and 1982 have been examined retrospectively. Follow-up data were available relative to recurrence rate, site of recurrence, and disease-free intervals. Fifty-nine percent of the patients with N1 cervical metastases had ECS. Patients were classified according to the histopathologic findings in the radical neck dissection specimens. The three groups identified were patients with normal nodes, patients with no ECS, and patients with ECS. The histopathologic evidence of ECS was associated with a statistically significant reduction in survival when compared with patients without ECS. The disease-free interval between treatment and the development of recurrent disease was shorter for patients with ECS than for patients with no ECS.
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
January 2020,
Frontiers in oncology,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
October 2003,
Ultraschall in der Medizin (Stuttgart, Germany : 1980),
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
January 2005,
The American journal of surgical pathology,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
October 2005,
The Journal of urology,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
August 1997,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
April 1979,
American journal of obstetrics and gynecology,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
December 2010,
International journal of radiation oncology, biology, physics,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
January 1991,
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
January 2002,
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
J T Johnson, and
E N Myers, and
C D Bedetti, and
E L Barnes, and
V L Schramm, and
P B Thearle
October 1990,
Oncology (Williston Park, N.Y.),
