Biomaterial Database

Virus-like particles in human vestibular ganglion cells. 1985

K Kitamura, and M Toriyama

We found intracytoplasmic aggregates of virus-like particles in human vestibular ganglion cells. These particles were always observed in the peripheral area of the cytoplasm. Morphological characteristics of the cytoplasm are similar to those of other ganglion cells. The inclusion bodies are round and measure about 1.7 micron in maximum diameter. They consist of a porous convoluted dense material and virus-like particles. The overall diameter of 118 randomly selected particles varies from 36 nm to 73 nm, and the mean value is 53 nm. Most of the particles are spherical while a few possess a hexagonal or semicircular profile. The particles exhibit a double external membrane or vesiculated external layer. Most of the particles are empty. There are, however, some particles which show vesicular structures in their content. Although our present data are insufficient to determine these particles as viral, their hexagonal shape and size are similar to true virus. With these data in mind, we suggest that these particles might be a dormant form of virus and may possibly produce infectious disease in the inner ear.

UI	MeSH Term	Description	Entries
D007181	Inclusion Bodies, Viral	An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.	Negri Bodies,Viral Inclusion Bodies,Negri Body,Bodies, Negri,Bodies, Viral Inclusion,Body, Negri,Body, Viral Inclusion,Inclusion Body, Viral,Viral Inclusion Body
D008297	Male		Males
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D005724	Ganglia	Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D014725	Vestibular Nerve	The vestibular part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The vestibular nerve fibers arise from neurons of Scarpa's ganglion and project peripherally to vestibular hair cells and centrally to the VESTIBULAR NUCLEI of the BRAIN STEM. These fibers mediate the sense of balance and head position.	Scarpa's Ganglion,Ganglion, Scarpa's,Nerve, Vestibular,Nerves, Vestibular,Scarpa Ganglion,Scarpas Ganglion,Vestibular Nerves
D014771	Virion	The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.	Virus Particle,Viral Particle,Viral Particles,Particle, Viral,Particle, Virus,Particles, Viral,Particles, Virus,Virions,Virus Particles