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High-resolution phosphorus nuclear magnetic resonance spectroscopy was used to monitor noninvasively the local pH changes that occur in vivo throughout fracture repair in rats. During the healing of a fractured shaft of tibia, the pH of the fracture hematoma changed from 7.2 on day two to 7.5 on day 20, i.e., alkaline with respect to the pH of normal extracellular fluid. This did not occur in a hematoma created by the direct injection of blood. Deposition of radio-opaque callus occurred mainly during the alkaline phase. Abnormalities in the control of local pH may be important in the etiology of delayed union, and future forms of local therapy may be usefully directed toward influencing this parameter.
R J Newman, and
R B Duthie, and
M J Francis
March 1969,
Journal of molecular biology,
R J Newman, and
R B Duthie, and
M J Francis
January 1986,
Methods in enzymology,
R J Newman, and
R B Duthie, and
M J Francis
January 1994,
Methods in molecular biology (Clifton, N.J.),
R J Newman, and
R B Duthie, and
M J Francis
June 1962,
The Journal of biological chemistry,
R J Newman, and
R B Duthie, and
M J Francis
May 2001,
Journal of chromatography. B, Biomedical sciences and applications,
R J Newman, and
R B Duthie, and
M J Francis
January 1989,
Archives of orthopaedic and trauma surgery,
R J Newman, and
R B Duthie, and
M J Francis
August 1994,
Journal of pharmaceutical sciences,
R J Newman, and
R B Duthie, and
M J Francis
April 1976,
Archives of biochemistry and biophysics,
R J Newman, and
R B Duthie, and
M J Francis
December 1968,
Thrombosis et diathesis haemorrhagica,
R J Newman, and
R B Duthie, and
M J Francis
January 1978,
Methods in enzymology,
