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Mice were placed on an immunization schedule known to result in the production of antibodies directed against a variety of barbiturates (antibody binding capacity = 2.71 pmole 3H-phenobarbital bound/ml undiluted serum). The pharmacologic response to barbiturate in these actively immunized mice and suitably treated controls was investigates using rotarod apparatus for monitoring CNS depression. It was found that the response to pentobarbital in actively immunized mice was decreased, as reflected by an increase in the time the mice remained on the rotarod and a shift of the dose--response curve to the right. The decreased pharmacologic response to pentobarbital was not the result of changes in levels of the hepatic drug metabolism components. Furthermore, the alteration of pharmacologic response in actively immunized mice was selective for barbiturate and did not modify the ataxia produced by administration of another depressant agent, ethanol.
E J Flynn, and
K V Cerreta, and
S Spector
December 1955,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E J Flynn, and
K V Cerreta, and
S Spector
February 1979,
The Journal of parasitology,
E J Flynn, and
K V Cerreta, and
S Spector
September 1970,
Archives of environmental health,
E J Flynn, and
K V Cerreta, and
S Spector
January 1972,
Acta physiologica Academiae Scientiarum Hungaricae,
E J Flynn, and
K V Cerreta, and
S Spector
November 1998,
Biology of reproduction,
E J Flynn, and
K V Cerreta, and
S Spector
March 1965,
Journal of bacteriology,
E J Flynn, and
K V Cerreta, and
S Spector
September 1950,
American journal of hygiene,
E J Flynn, and
K V Cerreta, and
S Spector
August 1970,
Journal of the National Cancer Institute,
E J Flynn, and
K V Cerreta, and
S Spector
July 1992,
Immunology,
E J Flynn, and
K V Cerreta, and
S Spector
May 1976,
Endocrinology,
