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To study the usefulness of IgM hepatitis B core antibody (anti-HBc IgM) for detecting hepatitis B virus infections in infants of hepatitis B surface antigen (HBsAg) carrier mothers, serial serum samples from 86 infants of carrier mothers were tested for anti-HBc IgM with a highly specific enzyme immunoassay. Asymptomatic hepatitis B infection occurred frequently in infants under 12 mo of age. Anti-HBc IgM never became positive in 25 infants infected under 9 mo old. It was positive in only 1 of 6 infected at 9 mo and 4 of 13 infected at 12 mo of age. The IgM antibody lasted for less than 6 mo. Although the infection was delayed in 28 infants receiving hepatitis B immune globulin, the poor anti-HBc IgM response did not seem to be due to the immune prophylaxis. Our study clearly indicates the limitation of anti-HBc IgM for detecting acute hepatitis B infection in infants born to HBsAg carrier mothers.
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
January 1982,
Acta paediatrica Scandinavica,
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
September 1979,
Lancet (London, England),
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
April 1979,
Pediatrics,
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
January 1989,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
October 1984,
British medical journal (Clinical research ed.),
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
June 1984,
The Western journal of medicine,
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
January 1980,
Acta haematologica Polonica,
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
November 1985,
Gastroenterology,
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
March 1985,
Annals of internal medicine,
D S Chen, and
J L Sung, and
M Y Lai, and
J C Sheu, and
P M Yang, and
S C Lee, and
S H Chen, and
M H Chang, and
T M Ko, and
T Y Lee
July 1984,
Gastroenterology,
