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Acetyl-coenzyme A: choline O-acetyltransferase (EC 2.3.1.6) (ChAT) enzyme activity was measured in the nucleus basalis and other microscopically identified brain areas at various times after unilateral cortical lesions were made in the rat. Initially, a significant decrease in ChAT activity was detected in the nucleus basalis ipsilateral to the lesion. However, after 120 days ChAT activity had apparently recovered, as levels of the enzyme at that time were not significantly different from control values. No changes in ChAT activity could be detected in any of the other brain areas similarly studied. The significance of these findings and their relationship to the morphological changes seen in neurones of the nucleus basalis after cortical lesions are discussed.
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
April 1989,
Neuroscience letters,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
February 1988,
Journal of neurochemistry,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
October 1982,
Neuroscience,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
January 1983,
General pharmacology,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
January 1987,
Hearing research,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
April 1987,
Neuroscience research,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
December 1986,
Neuroscience,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
January 1982,
General pharmacology,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
July 1984,
Brain research,
P H Stephens, and
A C Cuello, and
M V Sofroniew, and
R C Pearson, and
P Tagari
January 1999,
Journal of neural transmission (Vienna, Austria : 1996),
