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The cerebrospinal fluid (CSF) pharmacokinetics of cytosine arabinoside (Ara-C) was determined in 8 patients with metastatic cancer in the central nervous system. High dose (3 gm/M2) one-hour intravenous infusions of Ara-C were given with serial CSF sampling obtained from indwelling Ommaya reservoirs. CSF was analyzed by high pressure liquid chromatography. Mean Ara-C elimination half life of 140 minutes in CSF was eight times longer than that in plasma. The peak mean CSF concentration of Ara-C (2.1 micrograms /ml) was about 7% of the plasma concentration (30 micrograms/ml). A total of 28 treatment courses were administered with minimal hematopoietic, gastrointestinal and neurological toxicities. A schedule of administration of 2 high-dose treatments 12 hours apart repeated every two weeks should maintain cytotoxic CSF concentrations which could prove useful in the management of CNS leukemia and lymphoma.
J A Lopez, and
E Nassif, and
P Vannicola, and
J G Krikorian, and
R P Agarwal
June 1987,
Seminars in oncology,
J A Lopez, and
E Nassif, and
P Vannicola, and
J G Krikorian, and
R P Agarwal
June 1985,
Seminars in oncology,
J A Lopez, and
E Nassif, and
P Vannicola, and
J G Krikorian, and
R P Agarwal
January 1983,
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J A Lopez, and
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J G Krikorian, and
R P Agarwal
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J A Lopez, and
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R P Agarwal
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J A Lopez, and
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P Vannicola, and
J G Krikorian, and
R P Agarwal
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J A Lopez, and
E Nassif, and
P Vannicola, and
J G Krikorian, and
R P Agarwal
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J A Lopez, and
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P Vannicola, and
J G Krikorian, and
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J A Lopez, and
E Nassif, and
P Vannicola, and
J G Krikorian, and
R P Agarwal
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J A Lopez, and
E Nassif, and
P Vannicola, and
J G Krikorian, and
R P Agarwal
October 1982,
Cancer,
