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The focal uptake by human atherosclerotic lesions of 125I bound to low density lipoproteins (LDL) can be demonstrated by external imaging. However, 125I has poor imaging characteristics. Therefore, we have developed a technique for labeling LDL with technetium. To facilitate analysis, LDL was first labeled with 99mTc, by reduction of TcO4- with dithionite in the presence of the protein. The labeled LDL was stable to electrophoresis, ultracentrifugation, and passage in vivo. This technique was repeated with minor modification with 99mTc to prepare [99mTc] LDL for use as an imaging agent. Its biodistribution in 16 rabbits was similar to that of [125I] LDL and it allowed high resolution external imaging of LDL uptake by tissues, including the injured, healing, arterial wall, and the adrenal cortex.
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H D Garabedian, and
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D J Schumacher, and
A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
April 1986,
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R S Lees, and
H D Garabedian, and
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D J Schumacher, and
A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
April 2004,
European biophysics journal : EBJ,
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J L Isaacsohn, and
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H W Strauss
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R S Lees, and
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A M Lees, and
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A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
September 1996,
Atherosclerosis,
R S Lees, and
H D Garabedian, and
A M Lees, and
D J Schumacher, and
A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
July 1989,
Ceskoslovenska farmacie,
R S Lees, and
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A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
September 1990,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
R S Lees, and
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D J Schumacher, and
A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
August 1986,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
R S Lees, and
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A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
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R S Lees, and
H D Garabedian, and
A M Lees, and
D J Schumacher, and
A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
November 1990,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
R S Lees, and
H D Garabedian, and
A M Lees, and
D J Schumacher, and
A Miller, and
J L Isaacsohn, and
A Derksen, and
H W Strauss
September 1967,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
