-transparent.png){kind=logo}
Three chemical pathways were used for the synthesis of four new N'-(2-chloroethyl)-N-[2-(methylsulfinyl)ethyl]- and N'-(2-chloroethyl)-N-[2-(methylsulfonyl)ethyl]-N- or N'-nitrosoureas. These compounds are plasma metabolites of CNCC, a promising antineoplastic (2-chloroethyl)nitrosourea. Preliminary antitumor evaluation was performed against L1210 leukemia implanted intraperitoneally in mice. Among these compounds, two of them exhibited a greater antitumor activity compared to that of the parent mixture.
Related Publications
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
March 1979,
Journal of medicinal chemistry,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
May 1983,
Chemical & pharmaceutical bulletin,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
April 1982,
Journal of medicinal chemistry,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
July 1982,
Chemical & pharmaceutical bulletin,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
March 1987,
Journal of medicinal chemistry,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
December 1982,
Chemical & pharmaceutical bulletin,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
February 1982,
Chemical & pharmaceutical bulletin,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
December 1989,
Archiv der Pharmazie,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
November 1981,
Chemical & pharmaceutical bulletin,
J C Madelmont, and
D Godeneche, and
D Parry, and
J Duprat, and
J L Chabard, and
R Plagne, and
G Mathe, and
G Meyniel
January 1987,
Xenobiotica; the fate of foreign compounds in biological systems,
