Biomaterial Database

Effects of methamphetamine on dopamine cells in the substantia nigra pars compacta and the ventral tegmental area. 1985

K Kamata, and T Kameyama

The ability of methamphetamine to inhibit the firing rate of dopamine cells in the substantia nigra pars compacta (SNC) and the ventral tegmental area (VTA) was studied. Methamphetamine reduced the firing rates of the dopamine cells in a dose-dependent manner in the SNC and the VTA. The doses of methamphetamine required to produce a 50% inhibition of firing rate in the SNC and the VTA were 0.37 mg/kg and 0.28 mg/kg, respectively.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008694	Methamphetamine	A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.	Deoxyephedrine,Desoxyephedrine,Desoxyn,Madrine,Metamfetamine,Methamphetamine Hydrochloride,Methylamphetamine,N-Methylamphetamine,Hydrochloride, Methamphetamine,N Methylamphetamine
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D011954	Receptors, Dopamine	Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.	Dopamine Receptors,Dopamine Receptor,Receptor, Dopamine
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013378	Substantia Nigra	The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.	Nigra, Substantia,Nigras, Substantia,Substantia Nigras
D013681	Tegmentum Mesencephali	Portion of midbrain situated under the dorsal TECTUM MESENCEPHALI. The two ventrolateral cylindrical masses or peduncles are large nerve fiber bundles providing a tract of passage between the FOREBRAIN with the HINDBRAIN. Ventral MIDBRAIN also contains three colorful structures: the GRAY MATTER (PERIAQUEDUCTAL GRAY), the black substance (SUBSTANTIA NIGRA), and the RED NUCLEUS.	Accessory Oculomotor Nuclei,Annular Nucleus,Darkshevich's Nucleus,Interstitial Nucleus of Cajal,Mesencephalic Tegmentum,Mesencephalic Trigeminal Nucleus,Midbrain Tegmentum,Midbrain Trigeminal Nucleus,Nucleus Annularis,Nucleus Nervi Trochlearis,Nucleus Sagulum,Nucleus Tractus Mesencephalici Nervi Trigemini,Nucleus of Darkschewitsch,Peripeduncular Nucleus,Sagulum Nucleus,Tegmentum of Midbrain,Trochlear Nucleus,Ventral Tegmental Nucleus,Annulari, Nucleus,Annularis, Nucleus,Cajal Interstitial Nucleus,Darkschewitsch Nucleus,Darkshevich Nucleus,Darkshevichs Nucleus,Mesencephali, Tegmentum,Mesencephalic Tegmentums,Mesencephalus, Tegmentum,Midbrain Tegmentums,Nervi Trochleari, Nucleus,Nervi Trochlearis, Nucleus,Nuclei, Accessory Oculomotor,Nucleus Annulari,Nucleus Nervi Trochleari,Nucleus Sagulums,Nucleus, Annular,Nucleus, Darkshevich's,Nucleus, Mesencephalic Trigeminal,Nucleus, Midbrain Trigeminal,Nucleus, Peripeduncular,Nucleus, Sagulum,Nucleus, Trochlear,Nucleus, Ventral Tegmental,Oculomotor Nuclei, Accessory,Sagulum, Nucleus,Sagulums, Nucleus,Tegmental Nucleus, Ventral,Tegmentum Mesencephalus,Tegmentum, Mesencephalic,Tegmentum, Midbrain,Tegmentums, Mesencephalic,Tegmentums, Midbrain,Trigeminal Nucleus, Mesencephalic,Trigeminal Nucleus, Midbrain,Trochleari, Nucleus Nervi,Trochlearis, Nucleus Nervi
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus