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We have recently shown that dermorphin (D), a new potent opioid peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) stimulates prolactin (PRL) and growth hormone (GH) secretion in humans. In 11 patients with a PRL-secreting pituitary adenoma (eight microprolactinomas and three macroprolactinomas with suprasellar extension), diagnosed by pituitary dynamic function tests, and radiological evidence with confirmation at surgery, the PRL and GH responses to D were studied to evaluate the effect of pathological hyperprolactinemia on the opioid-induced secretion of GH and PRL. No PRL response to D was observed in all 11 patients. Plasma GH increased after D in all patients, except in three patients bearing a macroprolactinoma. This study shows that the effect of D on PRL and GH secretion can be dissociated in patients with PRL-secreting pituitary adenoma, perhaps for a different derangement in the hypothalamic-pituitary mechanism(s) underlying the opioidergic regulation of GH and PRL secretion. In addition our data indicate that D can be employed as a useful opioid probe in humans.
E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
R Tomatis, and
R Pansini
October 1982,
The Medical journal of Australia,
E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
R Tomatis, and
R Pansini
April 2020,
British journal of neurosurgery,
E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
R Tomatis, and
R Pansini
August 1986,
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E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
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R Pansini
July 1987,
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E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
R Tomatis, and
R Pansini
October 2002,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
E C degli Uberti, and
G Trasforini, and
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A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
R Tomatis, and
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July 2004,
International journal of radiation oncology, biology, physics,
E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
R Tomatis, and
R Pansini
May 2024,
The Journal of craniofacial surgery,
E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
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E C degli Uberti, and
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R Tomatis, and
R Pansini
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E C degli Uberti, and
G Trasforini, and
S Salvadori, and
A Margutti, and
C Rotola, and
M Bianconi, and
V Teodori, and
R Tomatis, and
R Pansini
December 2022,
Neuro endocrinology letters,
