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Osteosarcoma Arising in Noonan Syndrome/RASopathy Complex: First Case Report. 2025
Najwa Yousef, and
John Basile, and
Michael E Kallen, and
John F Caccamese, and
Donita Dyalram, and
Joshua Lubek, and
Farnaz Valaei, and
Jeffery Price, and
Layne N Raborn, and
Michael T Collins, and
Ahmed S Sultan
Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, USA.
BACKGROUND Noonan syndrome (NS) is a developmental malformation condition in the RASopathies group, characterized by variable clinical and molecular features. The syndrome is genetically heterogeneous, with the most frequent mutation found in approximately 50% of cases occurring in the PTPN11 gene. NS is reported to be associated with neurogenic, hematopoietic, melanocytic and other visceral malignancies, but osteosarcoma development has not been reported in association with NS. METHODS Therefore, we report the first case of a male with NS who developed osteosarcoma of the mandible in a background of long-standing polyostotic fibrous dysplasia (FD) of the craniofacial bones.
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