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Hairless mice with subcutaneously transplanted Lewis Lung carcinomas were used to study the effects of treatments with hematoporphyrin derivative (HPD) administered by intratumoral injection, followed by exposure to red light. A tumor cure rate of 70-90% was obtained following a single treatment. The therapeutic response increased with increasing HPD doses and light fluences. At a certain dose a plateau seemed to be reached, where further dose increase only gave a limited gain in treatment response. A narrow range seems to exist between beginning therapeutic response and frank necrotic destruction. The number of mice that died after treatment increased with increase in tumor size, and there was a correspondence between the time of death and the severity of the phototoxic reactions. The best therapeutic response was obtained when the irradiation was performed 1/2-1 h after injection, and with tumors less than 6-8 mm in diameter.
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G Volden, and
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September 1980,
Photochemistry and photobiology,
D Moseng, and
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K Midelfart, and
G Kavli, and
T Christensen, and
J Moan
January 1985,
Advances in experimental medicine and biology,
D Moseng, and
G Volden, and
K Midelfart, and
G Kavli, and
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July 1985,
Cancer research,
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December 1988,
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia,
D Moseng, and
G Volden, and
K Midelfart, and
G Kavli, and
T Christensen, and
J Moan
February 1987,
Cancer research,
D Moseng, and
G Volden, and
K Midelfart, and
G Kavli, and
T Christensen, and
J Moan
September 1988,
Journal of neuro-oncology,
D Moseng, and
G Volden, and
K Midelfart, and
G Kavli, and
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J Moan
January 1984,
Progress in clinical and biological research,
D Moseng, and
G Volden, and
K Midelfart, and
G Kavli, and
T Christensen, and
J Moan
January 1984,
Lasers in surgery and medicine,
D Moseng, and
G Volden, and
K Midelfart, and
G Kavli, and
T Christensen, and
J Moan
March 1986,
Chemico-biological interactions,
D Moseng, and
G Volden, and
K Midelfart, and
G Kavli, and
T Christensen, and
J Moan
November 1988,
Cancer biochemistry biophysics,
