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It is shown that in [14C]adenine-labelled thymocytes adenosine increases the content of adenine nucleotides and simultaneously accelerates their catabolism. Papaverine induces acceleration of splitting and a decrease of the specific ATP radioactivity but increases the AMP content and its specific radioactivity. The both effectors intensify considerably the outlet of total radioactive label from cells. If the papaverine effect in the extracellular medium results in accumulation mainly of hypoxanthine in the extracellular medium then the adenosine presence causes accumulation of inosine and hypoxanthine approximately in equal amounts. The release of labelled adenosine from thymocytes in all cases is an insignificant part of extracellular radioactivity. A conclusion is drawn that under conditions of the combined action of the substances under study papaverine removes the adenosine effect caused by its under study papaverine removes the adenosine effect caused by its phosphorylation with the formation of ATP and exerts the dose-depended action on adenine nucleotide metabolism in thymocytes.
N P Dmitrienko, and
T V Goroshnikova
August 1984,
Biokhimiia (Moscow, Russia),
N P Dmitrienko, and
T V Goroshnikova
January 1987,
Ukrainskii biokhimicheskii zhurnal (1978),
N P Dmitrienko, and
T V Goroshnikova
August 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
N P Dmitrienko, and
T V Goroshnikova
January 1971,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
N P Dmitrienko, and
T V Goroshnikova
February 1985,
Biokhimiia (Moscow, Russia),
N P Dmitrienko, and
T V Goroshnikova
August 1978,
Biochemical and biophysical research communications,
N P Dmitrienko, and
T V Goroshnikova
January 1982,
Life sciences,
N P Dmitrienko, and
T V Goroshnikova
January 1975,
Genetika,
N P Dmitrienko, and
T V Goroshnikova
May 1981,
Neuroscience letters,
N P Dmitrienko, and
T V Goroshnikova
June 1965,
The Biochemical journal,
