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By feeding adult male rats a calcium deficient diet for a period of 6 weeks osteoporosis can be induced with respect to significant changes in mass, turnover, chemical composition, and morphology of bone and parathyroid glands. When subsequently treating the osteoporotic rats with a combination of 1-alpha-OH-cholecalciferol (1-alpha-OH-D3) and optimal calcium intake osteoporosis as well as morphologic changes of parathyroids can be almost totally reversed as soon as after 2 weeks and completely after 4 and 6 weeks. Notwithstanding the change to an optimal calcium intake seems to be more important in normalizing the osteoporotic skeleton resulting from calcium deficiency than is the ingestion of 1-alpha-OH-D3, which may per se induce new bone formation.
T S Lindholm, and
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T C Lindholm
January 1979,
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T S Lindholm, and
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T C Lindholm
January 1987,
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T S Lindholm, and
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T S Lindholm, and
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T S Lindholm, and
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March 1994,
Clinical orthopaedics and related research,
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April 2006,
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T S Lindholm, and
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T S Lindholm, and
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T C Lindholm
April 1979,
Calcified tissue international,
T S Lindholm, and
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June 2019,
Medicina (Kaunas, Lithuania),
T S Lindholm, and
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T C Lindholm
March 1991,
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