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In beta-thalassemic homozygotes, low plasma levels of tocopherols may induce a red blood cell (RBC) lipid peroxidation and consequent hemolysis. This is an indication to treat these patients with vitamin E. In this study 26 beta-thalassemic homozygotes aged 2-14 years, were given vitamin E, 10 orally and 16 parenterally, 300 mg per day for 15 days. Prior to administration and blood transfusion, as compared to normal subjects of the same age, plasma and RBC tocopherols were significantly lower, whereas RBC malonyldialdehyde (MDA) was significantly increased. In both groups, after tocopherol administration, an increase in plasma and RBC tocopherols and a decrease in RBC MDA were found. The significance of these variations was greater in the parenterally treated group than in orally treated group. The treatment with vitamin E, appears to be effective to reduce the RBC oxidative damage in homozygous beta-thalassemia, principally when administered parenterally perhaps because of its poor intestinal absorption in these subjects.
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
January 1982,
Acta vitaminologica et enzymologica,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
August 1976,
Nuklearmedizin. Nuclear medicine,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
November 1985,
American journal of clinical pathology,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
February 1979,
Haematologica,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
July 2001,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
January 1981,
Nouvelle revue francaise d'hematologie,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
January 1985,
Haematologica,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
June 1977,
Helvetica paediatrica acta,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
March 2011,
Iranian journal of pediatrics,
O Giardini, and
A Cantani, and
A Donfrancesco, and
F Martino, and
O Mannarino, and
P D'Eufemia, and
C Miano, and
U Ruberto, and
R Lubrano
April 2023,
Hematology/oncology clinics of North America,
