Seventy-five crossbred heifers (mean weight 304 kg) were stratified by weight and source and placed in eight pens. Four duplicate treatments were randomly assigned to pens as follows: (1) intact-control (n = 19), (2) intact + melengestrol acetate (MGA, n = 20), (3) hysterectomy (n = 17) and (4) ovariectomy (OVX, n = 19). All heifers were preconditioned for 2 mo before beginning the finishing study. Surgery was performed through a high lumbar incision approximately 3 wk before the finishing study began. Group 2 heifers were fed .4 mg X head-1 X d-1 MGA. Blood samples were collected at 28-d intervals throughout the 112-d finishing phase. Ovaries were collected at slaughter and carcass data were obtained 24 h after slaughter. On d 112, progesterone was higher (P less than .05) in hysterectomized heifers than in other treatment groups. Serum progesterone concentration was nondetectable (less than .35 ng/ml) in OVX and MGA heifers. There were no differences (P greater than .05) in feed efficiency or carcass characteristics among the four treatments. Hysterectomized and MGA heifers had similar (P greater than .05) average daily gains, which were higher (P less than .15) than control and OVX heifers. These data suggest that the elevated levels of progesterone from the maintained corpora lutea and the subsequent absence of estrous activity in the hysterectomized heifers are advantageous for promoting growth in feedlot heifers.