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Intravenous metoclopramide and IM prochlorperazine and diazepam were compared in the management of vomiting occurring during treatment with cis-dichlorodiammineplatinum (cis-platinum). A total of 104 cycles in 30 patients were evaluated. Twenty-two patients took part in a cross-over study in which emetic profiles for each patient managed with each anti-emetic schedule were compared. In all, 44 cycles of treatment in 22 patients were evaluated as part of a cross-over study. No significant difference in emetic control was observed between the two anti-emetic regimens. The side-effects observed using IV metoclopramide included extrapyramidal phenomena (19%) and flushing attacks (16%).
D M Luesley, and
P B Terry, and
K K Chan
January 1985,
Neoplasma,
D M Luesley, and
P B Terry, and
K K Chan
January 1991,
Oncology,
D M Luesley, and
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K K Chan
September 1992,
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D M Luesley, and
P B Terry, and
K K Chan
January 1988,
Oncology,
D M Luesley, and
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K K Chan
July 1988,
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D M Luesley, and
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February 1985,
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D M Luesley, and
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D M Luesley, and
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D M Luesley, and
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K K Chan
March 1987,
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D M Luesley, and
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K K Chan
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