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The tissue cis-diamminedichloroplatinum (II) (CDDP) concentration was measured in autopsies treated with CDDP therapy for gynecological malignancies. These cases consisted of 10 of ovarian tumor and one of choriocarcinoma. Total CDDP doses administered were from 55mg to 560mg and among them three cases were treated with more than 500mg (525mg, 555mg in ovarian cancer and 560mg in choriocarcinoma). We found moderate renal impairment with this drug by serum functional test and histopathology, although these changes did not correspond with the total doses. In liver, kidney and residual tumor measured for CDDP, the tissue concentration was highest in liver. When total doses administered were compared with the tissue concentration in liver, kidney, residual tumor and the decrease in creatinine clearance value, there were statistically significant differences only in residual tumor at p less than 0.01.
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
January 1982,
The Netherlands journal of medicine,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
January 1982,
The Netherlands journal of medicine,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
January 1984,
Cancer chemotherapy and pharmacology,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
August 1990,
Zhonghua er bi yan hou ke za zhi,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
February 1983,
Cancer research,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
November 1990,
Journal of comparative pathology,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
January 1986,
Cancer chemotherapy and pharmacology,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
June 1973,
Cancer research,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
October 1996,
Toxicology and applied pharmacology,
S Kodama, and
N Obata, and
T Hando, and
T Ikarashi, and
A Goto, and
S Takeuchi
March 1979,
Cancer treatment reviews,
