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Water containing 20% ethanol was given for a period of 3, 6 and 9 weeks to rats, and changes in hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferases were investigated. Lipid peroxide levels and glutathione peroxidase activities remained unchanged after 3 weeks and started to increase thereafter. Glutathione levels and glutathione transferase activities were significantly increased following ethanol consumption. These results show that chronic ethanol consumption stimulates hepatic lipid peroxidation in rats. This stimulation is not dependent on glutathione depletion and the increased glutathione peroxidase and glutathione transferase activities may reflect an adaptive change against ethanol-induced lipid peroxide toxicity.
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
January 1988,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
September 1973,
FEBS letters,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
March 2006,
Current therapeutic research, clinical and experimental,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
October 1985,
Biochemical pharmacology,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
March 1990,
Agents and actions,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
February 1981,
Clinica chimica acta; international journal of clinical chemistry,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
December 1997,
Doklady Akademii nauk,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
August 1984,
Research communications in chemical pathology and pharmacology,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
January 1990,
Biochemistry international,
G Aykaç, and
M Uysal, and
A S Yalçin, and
N Koçak-Toker, and
A Sivas, and
H Oz
January 2000,
Drug metabolism and drug interactions,
