Biomaterial Database

Proactive behavioral effects of theta-driving septal stimulation on conditioned suppression and punishment in the rat. 1985

L Holt, and J A Gray

In two experiments, a treatment phase of septal stimulation preceded the acquisition of free operant lever pressing on a random-interval 64-s reinforcement schedule. Male Sprague-Dawley rats, chronically implanted with a bilateral septal stimulating electrode and a unilateral bipolar hippocampal recording electrode, received (a) low-frequency (7.7-Hz) stimulation, which drove the hippocampal theta rhythm, or (b) random-pulse stimulation (average frequency = 7.7 Hz), which produced only nonregular waveforms in the hippocampus. Control animals were implanted but not stimulated. After 12 days of lever-press acquisition, animals were presented while lever pressing with an auditory signal associated with a particular schedule of shock delivery: In Experiment 1, shocks occurred despite the subject's response strategy; in Experiment 2, shocks were delivered only if the rat pressed the lever. In both experiments, lever pressing was suppressed by the auditory stimulus. Theta-driving but not random-pulse septal stimulation proactively increased behavioral tolerance to the effects of electric shock. These results reinforce the idea that proactive behavioral effects of septal stimulation are a consequence of the production of the hippocampal theta rhythm.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009434	Neural Pathways	Neural tracts connecting one part of the nervous system with another.	Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D011678	Punishment	The application of an unpleasant stimulus or penalty for the purpose of eliminating or correcting undesirable behavior.	Punishments
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D001931	Brain Mapping	Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.	Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D003216	Conditioning, Operant	Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.	Instrumental Learning,Learning, Instrumental,Operant Conditioning,Conditionings, Operant,Instrumental Learnings,Learnings, Instrumental,Operant Conditionings
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D005239	Fear	The affective response to an actual current external danger which subsides with the elimination of the threatening condition.	Threat Cues,Threat Sensitivity,Cue, Threat,Fears,Sensitivity, Threat,Threat Cue,Threat Sensitivities
D005639	Frustration	The motivational and/or affective state resulting from being blocked, thwarted, disappointed or defeated.	Frustrations
D006624	Hippocampus	A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.	Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums