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The ability of human and rabbit alveolar macrophages to dissolve 0.1-0.5 micron MnO2 particles in vitro was compared. The amount of Mn added and dissolved from the particles over periods of nought, one, and three days was determined by flame atomic absorption spectrophotometry. The amount dissolved by human and rabbit macrophages was similar; on average 43.1% and 43.9%, respectively, were dissolved within three days. But rabbit and human macrophages dissolved significantly more Mn than was dissolved in the respective culture medium without macrophages after one and three days. It is suggested that the dissolution of particles by alveolar macrophages should be one basic component in any model of alveolar clearance of inorganic particles.
M Lundborg, and
A Eklund, and
B Lind, and
P Camner
April 1987,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
M Lundborg, and
A Eklund, and
B Lind, and
P Camner
January 1984,
Experimental lung research,
M Lundborg, and
A Eklund, and
B Lind, and
P Camner
May 1990,
American journal of respiratory cell and molecular biology,
M Lundborg, and
A Eklund, and
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P Camner
July 1992,
Environmental health perspectives,
M Lundborg, and
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P Camner
March 1982,
Proceedings of the National Academy of Sciences of the United States of America,
M Lundborg, and
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P Camner
January 1976,
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M Lundborg, and
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P Camner
July 1992,
Environmental health perspectives,
M Lundborg, and
A Eklund, and
B Lind, and
P Camner
December 1977,
Life sciences,
M Lundborg, and
A Eklund, and
B Lind, and
P Camner
July 1992,
Environmental health perspectives,
M Lundborg, and
A Eklund, and
B Lind, and
P Camner
June 1975,
Infection and immunity,
