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A study was made of the action of the antidiabetic biguanide phenformin, clofibrate and the phospholipid drug Essentiale on the basal and adrenaline-stimulated activity of adenylate cyclase in Ehrlich's ascites carcinoma cells. All the drugs under study potentiated the hormone-stimulated activity of adenylate cyclase. Unlike phenformin and Essentiale, clofibrate did not exert any effect on the basal activity of adenylate cyclase. On the other hand, certain differences were revealed in changes of the lipid content of tumor cells during application of the drugs in question. Stimulation of adenylate cyclase activity by hypolipidemic drugs is regarded as a promising approach to the goal-oriented changing of hormonal sensitivity of tumor cells.
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
August 1981,
The Journal of clinical endocrinology and metabolism,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
November 1973,
Biochimica et biophysica acta,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
August 1987,
General and comparative endocrinology,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
October 1987,
Acta endocrinologica,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
February 1986,
Biochemical and biophysical research communications,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
October 1999,
Acta neuropathologica,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
December 1983,
Journal of molecular and cellular cardiology,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
February 1974,
Biochemical pharmacology,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
January 1990,
Chronobiology international,
L M Bershteĭn, and
I G Kovaleva, and
O A Rozenberg
October 1981,
Acta pharmacologica et toxicologica,
