-transparent.png){kind=logo}
Interaction of rabbit alveolar macrophages (AM) with homologous fibronectin bound to gelatin-sepharose granules was studied. Macrophages obtained at the height of anaphylactic shock and cells from sensitized animals after preincubation with antigen or histamine failed to adhere to the fibronectin-coated surface. AM from intact and sensitized animals were capable of adhering to the fibronectin-coated granules in a Ca2+, Mg2+-dependent manner. Pretreatment of intact cells with trypsin inhibited AM-fibronectin interaction. The data indicate that the surface of AM bears protein receptors, capable of interacting with fibronectin, which change their affinity during anaphylactic shock and under the effect of histamine. It may be thus concluded that fibronectin is involved in the function of mononuclear phagocytes in health, evidence that complements the idea of the role played by macrophages in the pathogenesis of the immediate type hypersensitivity.
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
November 1922,
The Journal of experimental medicine,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
May 1969,
Archives internationales de physiologie et de biochimie,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
October 2011,
British journal of anaesthesia,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
January 1970,
Fiziologia normala si patologica,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
May 1989,
Journal of occupational medicine. : official publication of the Industrial Medical Association,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
January 1958,
Biulleten' eksperimental'noi biologii i meditsiny,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
July 1978,
Kardiologiia,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
August 1972,
Klinicheskaia meditsina,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
January 1993,
Gematologiia i transfuziologiia,
L D Zubairova, and
O D Zinkevich, and
R I Litvinov
January 1967,
Arerugi = [Allergy],
