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Using a double-bolus technique, the efficacy and safety of epidural fentanyl with and without epinephrine 1:400,000 for post-Caesarean section analgesia was examined in 30 patients. The addition of 25 micrograms epinephrine to the fentanyl (100 micrograms) did not potentiate the speed of onset but did significantly prolong the duration of action of the second dose. The only side effect encountered was pruritus, which was significantly increased (from 17-44 per cent) when epinephrine was added. The results indicate a clinical advantage of prolonging the duration of action of fentanyl for post-Caesarean Section analgesia with the addition of epinephrine, but the cumbersome and time-consuming nature of a double-bolus technique limits its clinical value. The relative safety of epidural fentanyl with and without epinephrine was confirmed by the absence of respiratory depression, drowsiness or hypotension in all patients.
K Robertson, and
M J Douglas, and
G H McMorland
May 1990,
Canadian journal of anaesthesia = Journal canadien d'anesthesie,
K Robertson, and
M J Douglas, and
G H McMorland
June 1989,
Anaesthesia,
K Robertson, and
M J Douglas, and
G H McMorland
January 1946,
British journal of anaesthesia,
K Robertson, and
M J Douglas, and
G H McMorland
May 2000,
Anaesthesia,
K Robertson, and
M J Douglas, and
G H McMorland
February 1992,
Anesthesia and analgesia,
K Robertson, and
M J Douglas, and
G H McMorland
September 1990,
Ma zui xue za zhi = Anaesthesiologica Sinica,
K Robertson, and
M J Douglas, and
G H McMorland
August 2005,
Singapore medical journal,
K Robertson, and
M J Douglas, and
G H McMorland
March 1999,
British journal of anaesthesia,
K Robertson, and
M J Douglas, and
G H McMorland
August 2001,
Anaesthesia,
K Robertson, and
M J Douglas, and
G H McMorland
July 2007,
Anaesthesia,
