Biomaterial Database

Hemodynamic and acid-base effects of promazine on unanesthetized pregnant sheep and fetus. 1985

J Ayromlooi

Although promazine has been used in obstetrics for over 20 years, its effects upon hemodynamic and acid-base conditions of steady-state pregnant sheep and fetus has not been sufficiently investigated. To study these effects, 10 experiments were performed in 5 ewes and their fetuses. Promazine (1 mg/kg/4 min) was administered intravenously to the ewes. Significant maternal changes included: reduction in hemoglobin from 9.1 +/- 0.43 to 8.4 +/- 0.43 g/100 ml at 120 min, O2 content from 12.1 +/- 0.61 to 10.8 +/- 0.59 vol% at 90 min, O2 saturation from 9.7 +/- 2.58 to 95.4 +/- 2.80% at 15 min, and blood pressure from 86.1 +/- 4.94 to 74.1 +/- 2.55 mm Hg at 45 min. The heart rate increased from 84 +/- 2.64 to 100 +/- 5.03 beats/min at 120 min. The uterine blood flow remained unchanged. The fetus developed mild metabolic acidosis as manifested by the reduction in pH from 7.375 +/- 0.008 to 7.35 +/- 0.005 at 45 min. No other fetal hemodynamic changes were observed. The significance of these findings is discussed.

UI	MeSH Term	Description	Entries
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011395	Promazine	A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.	Promazine Hydrochloride,Protactyl,Sinophenin,Sparine,Hydrochloride, Promazine
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005260	Female		Females
D005333	Fetus	The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.	Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations