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A 49-year-old woman treated with cimetidine 300 mg tid for more than 18 months for Zollinger-Ellison syndrome experienced lethargy, dizziness, ataxia, and auditory and visual hallucinations after receiving triazolam 0.375 mg hs for sleep. Triazolam plasma concentrations were measured, and a triazolam elimination half-life was calculated to be approximately 8 hours (reported range 1.7-3 h). Cimetidine has been reported to decrease the apparent oral clearance of triazolam, resulting in increased triazolam plasma concentrations with the potential for exaggerated triazolam pharmacologic effects. Cimetidine may have been responsible for the unusually large elimination half-life in this patient. Until the mechanisms and clinical significance of this potential drug interaction are determined, clinicians should use the combination of triazolam and cimetidine with caution.
M L Britton, and
E S Waller
January 2011,
The Annals of pharmacotherapy,
M L Britton, and
E S Waller
March 1979,
The American journal of psychiatry,
M L Britton, and
E S Waller
January 1994,
Pharmacotherapy,
M L Britton, and
E S Waller
January 1969,
Transactions of the American Neurological Association,
M L Britton, and
E S Waller
March 1988,
The New England journal of medicine,
M L Britton, and
E S Waller
July 1980,
Annals of internal medicine,
M L Britton, and
E S Waller
January 1985,
Lancet (London, England),
M L Britton, and
E S Waller
June 1981,
General hospital psychiatry,
M L Britton, and
E S Waller
September 1978,
The Journal of pediatrics,
M L Britton, and
E S Waller
August 1986,
Anesthesia and analgesia,
