Biomaterial Database

Responses of cerebellar fastigial neurons to single muscle activation. 1985

F Licata, and G Occhipinti, and F Santangelo

In lightly barbiturized cats, the discharges of neurons in the cerebellar fastigial nucleus (CBM) were recorded while single muscles in ipsilateral forelimb were activated by direct stimulation. The aim was to verify whether CBM cells could selectively detect the activity of afferent fibers from a muscle or a joint and to compare the various response characteristics of the rostral and the caudal division of the nucleus, which are known to control a different muscular periphery. Six muscles were routinely tested, two axial, two proximal and two distal ones. A good percentage of neurons in both partitions of the nucleus responded to the muscles tested (53% and 48% in the rostral and caudal part, respectively). In the rostral part of CBM a large proportion of cells (78% of those responsive) were influenced by one or more muscles having either the same function (the extensors or flexors) or acting on the same joint. Many such neurons showed a marked capability to respond to activation of distal muscles and a prevalence of inhibitory responses mainly on contraction of extensor and axial muscles. In the caudal division of the nucleus, 47% of the responsive cells displayed a stereotyped discharge pattern (excitatory or inhibitory) in response to activation of any tested muscle. In contrast to the rostral CBM the incidence of responses to proximal and distal muscles was about equal in the caudal CBM and a majority of neurons had excitatory responses to flexor muscle contraction. The latencies of the excitatory effects ranged from 8 to 53 ms in rostral and 9 up to 69 ms in caudal CBM.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D007596	Joints	Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.	Joint
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009433	Neural Inhibition	The function of opposing or restraining the excitation of neurons or their target excitable cells.	Inhibition, Neural
D009475	Neurons, Afferent	Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.	Afferent Neurons,Afferent Neuron,Neuron, Afferent
D011930	Reaction Time	The time from the onset of a stimulus until a response is observed.	Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D001931	Brain Mapping	Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.	Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002529	Cerebellar Nuclei	Four clusters of neurons located deep within the WHITE MATTER of the CEREBELLUM, which are the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.	Dentate Nucleus,Nucleus Dentatus,Nucleus Emboliformis,Nucleus Fastigii,Nucleus Globosus,Amiculum of the Dentate Nucleus,Anterior Interposed Nucleus,Anterior Interpositus Nucleus,Central Nuclei,Deep Cerebellar Nuclei,Dentate Cerebellar Nucleus,Fastigial Cerebellar Nucleus,Fastigial Nucleus,Intracerebellar Nuclei,Lateral Cerebellar Nucleus,Medial Cerebellar Nucleus,Central Nucleus,Cerebellar Nuclei, Deep,Cerebellar Nucleus,Cerebellar Nucleus, Deep,Cerebellar Nucleus, Dentate,Cerebellar Nucleus, Fastigial,Cerebellar Nucleus, Lateral,Cerebellar Nucleus, Medial,Deep Cerebellar Nucleus,Emboliformis, Nucleus,Fastigii, Nucleus,Globosus, Nucleus,Interposed Nucleus, Anterior,Interpositus Nucleus, Anterior,Intracerebellar Nucleus,Nuclei, Central,Nuclei, Cerebellar,Nuclei, Deep Cerebellar,Nuclei, Intracerebellar,Nucleus Fastigius,Nucleus, Anterior Interposed,Nucleus, Anterior Interpositus,Nucleus, Central,Nucleus, Cerebellar,Nucleus, Deep Cerebellar,Nucleus, Dentate,Nucleus, Dentate Cerebellar,Nucleus, Fastigial,Nucleus, Fastigial Cerebellar,Nucleus, Intracerebellar,Nucleus, Lateral Cerebellar,Nucleus, Medial Cerebellar
D005246	Feedback	A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.	Feedbacks