Biomaterial Database

Effect of acute and chronic oral administration of ethanol on canine exocrine pancreatic secretion. 1985

G Robles Diaz, and M A Devaux, and H Sarles

The action of an intragastric injection of ethanol (1.0-1.5 g/kg), either in the fasting animal or with a solid meal, has been studied in two groups of 4 conscious dogs provided with gastric and duodenal Thomas cannulae: one group of 'alcoholic dogs' (AD) had been given 2 g/kg/day ethanol over a period of 24 months, the second group of 'nonalcoholic dogs' (NA) had been given water as control. In NA, intragastric ethanol inhibited water and bicarbonate secretions, alcohol being given in the fasting animal or with a meal. In AD: (a) the nonstimulated output of water and bicarbonate, and to a lesser extent of protein, was decreased compared to NA, protein concentration being increased; (b) the bicarbonate response to a meal without ethanol was decreased, and (c) the most interesting finding is that in AD, the inhibitory action of intragastric ethanol as observed in NA, disappeared and was even replaced by a stimulation of water, bicarbonate and protein secretions. The disappearance in AD of alcohol-induced mechanisms inhibiting pancreatic secretion had already been found with other experimental protocols and involves muscarinic receptors. Inhibition of water and bicarbonate secretions remains unexplained.

UI	MeSH Term	Description	Entries
D007263	Infusions, Parenteral	The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.	Intra-Abdominal Infusions,Intraperitoneal Infusions,Parenteral Infusions,Peritoneal Infusions,Infusion, Intra-Abdominal,Infusion, Intraperitoneal,Infusion, Parenteral,Infusion, Peritoneal,Infusions, Intra-Abdominal,Infusions, Intraperitoneal,Infusions, Peritoneal,Intra Abdominal Infusions,Intra-Abdominal Infusion,Intraperitoneal Infusion,Parenteral Infusion,Peritoneal Infusion
D007267	Injections	Introduction of substances into the body using a needle and syringe.	Injectables,Injectable,Injection
D008297	Male		Males
D010179	Pancreas	A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D011506	Proteins	Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.	Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005215	Fasting	Abstaining from FOOD.	Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D005260	Female		Females
D005502	Food	Substances taken in by the body to provide nourishment.	Foods
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations