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The ability of chloroquine to inhibit the activation of the complement and coagulation systems was investigated. The activation of the classical pathway of complement by antibody coated sheep erythrocytes and aggregated IgG was blocked by chloroquine. Similarly, it prevented normal rabbit erythrocytes and zymosan from activating the the alternative pathway of complement. The activation of C3 by immune complexes of different solubilities also was inhibited by this drug. In addition, it abrogated the clotting of plasma by calcium chloride and thrombin. This effect could be reversed by the addition of excess thrombin but not of calcium chloride. It is suggested that the inhibition of these two important phlogistic mediator systems of inflammation may contribute to the anti-inflammatory property of chloroquine.
V D Ramanathan, and
U Sengupta
January 1997,
Shock (Augusta, Ga.),
V D Ramanathan, and
U Sengupta
October 1977,
Journal of biochemistry,
V D Ramanathan, and
U Sengupta
January 2023,
Respiration; international review of thoracic diseases,
V D Ramanathan, and
U Sengupta
May 1991,
Undersea biomedical research,
V D Ramanathan, and
U Sengupta
May 2006,
Virology journal,
V D Ramanathan, and
U Sengupta
February 2019,
Journal of immunology (Baltimore, Md. : 1950),
V D Ramanathan, and
U Sengupta
January 2009,
Immunology and cell biology,
V D Ramanathan, and
U Sengupta
February 1997,
Transfusion,
V D Ramanathan, and
U Sengupta
October 1982,
Thrombosis and haemostasis,
