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The cytogenetic characterization of the L5178Y TK+/-3.7.2C mouse lymphoma cell line was carried out, utilizing G-banded metaphase chromosomes, to provide a karyotypic basis for the precise delineation of induced rearrangements in TK-/- mutants. Band-pattern measurements were used to construct ideograms which represent the position, number, size and staining intensity of the chromosome bands. The TK+/-3.7.2C cell line has been shown to provide quantitation of forward mutations induced at the autosomal thymidine kinase (TK) locus in this cell line. Chromosome analysis of the TK+/-3.7.2C cell line and derived TK-/- mutants has become important in demonstrating that the TK+/-----TK-/- assay may detect and distinguish between chromosomal events and smaller, perhaps point-mutation, events in mutant colonies.
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
January 2013,
Methods in molecular biology (Clifton, N.J.),
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
January 1987,
Environmental mutagenesis,
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
January 1987,
Mutation research,
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
January 2020,
Methods in molecular biology (Clifton, N.J.),
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
March 1987,
Mutation research,
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
December 1989,
Mutation research,
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
March 1986,
Mutagenesis,
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
November 1990,
Mutagenesis,
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
February 2017,
Mutation research. Genetic toxicology and environmental mutagenesis,
J Sawyer, and
M M Moore, and
D Clive, and
J Hozier
May 2003,
Mutation research,
