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Using phosphorus nuclear magnetic resonance spectroscopy, we studied the muscle metabolism in four patients with paramyotonia congenita as reflected in the PC/Pi and PC/ATP ratios. At normal body temperature, all results were indistinguishable from controls. After cooling to 29 degrees C muscle temperature and a single 2-sec maximum contraction, the forearm muscles were stiff. At this stage, no decrease in the ATP content could be detected. In greater than 50% of the experiments with patients, an additional peak occurred transiently at the resonant frequency for monophosphates. After a working period at 29 degrees C muscle temperature, the paramyotonic muscles were paralyzed, but displayed spectra similar to those obtained at normal body temperature and full working capability. Intracellular pH was close to 7 in paramyotonic muscle under all conditions examined.
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
January 1998,
Advances in experimental medicine and biology,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
April 2000,
Biophysical journal,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
May 1990,
Muscle & nerve,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
January 1993,
Basic research in cardiology,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
April 2014,
European journal of applied physiology,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
January 1990,
Basic life sciences,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
September 1987,
Therapie,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
February 1988,
The American journal of physiology,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
June 2015,
Scandinavian journal of medicine & science in sports,
F Lehmann-Horn, and
D Höpfel, and
R Rüdel, and
K Ricker, and
G Küther
May 1995,
Biochemical Society transactions,
