Biomaterial Database

Treatment of rheumatoid arthritis with gold. 1977

M Abeles, and J D Urman, and A Weinstein

There have been three important double-blind studies evaluating the use of gold therapy in rheumatoid arthritis. Patients treated with gold have decreased number of joints with synovitis, decreased ring size, increased grip strength, and roentgenographic evidence of arrest or decrease in the progression of skeletal lesions. If a patient with active synovitis does not respond to nonsteroidal anti-inflammatory drugs after four months of treatment, he is a candidate for gold therapy. Maintenance gold therapy has been shown to sustain clinical improvement. Patients must be monitored with appropiate laboratory tests.

UI	MeSH Term	Description	Entries
D009393	Nephritis	Inflammation of any part of the KIDNEY.	Nephritides
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D006052	Gold Sodium Thiomalate	A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.	Aurothiomalate,Gold Thiomalate,Sodium Gold Thiomalate,Aurolate,Gold Disodium Thiomalate, Monohydrate,Gold Thiomalic Acid,Mercaptobutanedioic Acid Monogold(1+) Sodium Salt,Miocrin,Miocrisin,Monogold (1+) Disodium Thiomalate,Myochrysine,Myocrisin,Myocrysine,Sodium Aurothiomalate,Sodium Thiomalatoaurate,Tauredon,Aurothiomalate, Sodium,Gold Thiomalate, Sodium,Sodium Thiomalate, Gold,Thiomalate, Gold,Thiomalatoaurate, Sodium
D006402	Hematologic Diseases	Disorders of the blood and blood forming tissues.	Blood Diseases,Hematological Diseases,Blood Disease,Disease, Blood,Disease, Hematologic,Disease, Hematological,Diseases, Blood,Diseases, Hematologic,Diseases, Hematological,Hematologic Disease,Hematological Disease
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis
D012871	Skin Diseases	Diseases involving the DERMIS or EPIDERMIS.	Dermatoses,Skin and Subcutaneous Tissue Disorders,Dermatosis,Skin Disease
D013585	Synovitis	Inflammation of the SYNOVIAL MEMBRANE.	Plica Syndrome,Synovial Plica Syndrome,Synovial Hypertrophy,Synovial Thickening,Hypertrophies, Synovial,Hypertrophy, Synovial,Plica Syndrome, Synovial,Synovial Hypertrophies,Synovial Thickenings,Synovitides,Thickening, Synovial,Thickenings, Synovial