Biomaterial Database

Open fractures of the extremities. The case for open treatment. 1985

J L Goldner, and W T Hardaker, and J D Mabrey

Meticulous care of open wounds in open fractures is essential to prevent development of infection. Wounds should be treated by early excision and early delayed or secondary closure. Primary closure is not necessarily beneficial and can actually increase the risk of infection. Culture for aerobic and anerobic organisms should be obtained at initial examination, and antibiotic treatment should be started before wound excision. The experience at Duke University Medical Center, Durham, North Carolina, during the past 40 years has demonstrated that open treatment of open wounds is safe and highly successful in preventing gas gangrene and osteomyelitis.

UI	MeSH Term	Description	Entries
D007869	Leg Injuries	General or unspecified injuries involving the leg.	Injuries, Leg,Injury, Leg,Leg Injury
D008297	Male		Males
D003131	Combined Modality Therapy	The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.	Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D003646	Debridement	The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)	Debridements
D005597	Fractures, Open	Fractures in which there is an external wound communicating with the break of the bone.	Fractures, Compound,Compound Fracture,Compound Fractures,Fracture, Compound,Fracture, Open,Open Fracture,Open Fractures
D005738	Gas Gangrene	A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.	Gangrene, Gas,Gangrenes, Gas,Gas Gangrenes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000046	Academic Medical Centers	Medical complexes consisting of medical school, hospitals, clinics, libraries, administrative facilities, etc.	Medical Centers, Academic,Medical Centers, University,University Medical Centers,Academic Medical Center,Center, Academic Medical,Center, University Medical,Centers, Academic Medical,Centers, University Medical,Medical Center, Academic,Medical Center, University,University Medical Center
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults