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Minimum inhibitory concentrations (MIC) of pirbenicillin against 135 clinical isolates of Pseudomonas aeruginosa were one-fourth of those required for carbenicillin but two times higher than those for BL-P1654. Increasing the inoculum size produced an adverse effect on the bactericidal activity for all three antibiotics. This was more apparent for pirbenicillin than for carbenicillin, but less than the effect on BL-P1654. When concentrations of antibiotics likely to be achieved clinically were used, gentamicin increased the inhibitory and bactericidal effects of all three semisynthetic penicillins for the majority of isolates. Strains highly resistant to the aminoglycoside antibiotic, however, were inhibited no more by the penicillin-gentamicin combinations than by the most effective of the antibiotics alone.
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
March 1975,
Antimicrobial agents and chemotherapy,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
October 1974,
Antimicrobial agents and chemotherapy,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
November 1974,
Antimicrobial agents and chemotherapy,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
October 1974,
Antimicrobial agents and chemotherapy,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
September 1976,
Antimicrobial agents and chemotherapy,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
September 1975,
Antimicrobial agents and chemotherapy,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
November 1974,
Annals of internal medicine,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
January 1982,
Annals of clinical and laboratory science,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
January 1979,
The Journal of antimicrobial chemotherapy,
C E Lopez, and
H C Standiford, and
B A Tatem, and
F M Calia, and
S C Schimpff, and
M J Snyder, and
R B Hornick
October 1976,
Antimicrobial agents and chemotherapy,
