-transparent.png){kind=logo}
1 Rectal administration of the new analgesic drug, meptazinol, resulted in rapid absorption of the compound both in the monkey and in man. Peak plasma levels were observed within 0.5 h of dosing. 2 Absorption of the drug following rectal administration was extensive as shown by the recovery of 65-90% of the dose in the urine. 3 Despite substantial inter-individual variation in the observed maximum plasma concentrations of the drug, it was still evident that concentrations after rectal dosage were considerably higher than when the same dosage was given orally. 4 Elimination of the drug from plasma took place rapidly in an apparently mono-exponential manner in both species. The half-life of elimination in monkeys was 1.25 h and in man 2.0 h.
R A Franklin, and
P J Southgate, and
A J Coleman
July 1981,
British journal of clinical pharmacology,
R A Franklin, and
P J Southgate, and
A J Coleman
September 1987,
British journal of anaesthesia,
R A Franklin, and
P J Southgate, and
A J Coleman
August 1979,
Acta pharmacologica et toxicologica,
R A Franklin, and
P J Southgate, and
A J Coleman
January 1989,
European journal of clinical pharmacology,
R A Franklin, and
P J Southgate, and
A J Coleman
January 1982,
European journal of clinical pharmacology,
R A Franklin, and
P J Southgate, and
A J Coleman
January 1982,
Pediatric pharmacology (New York, N.Y.),
R A Franklin, and
P J Southgate, and
A J Coleman
December 1951,
The Journal of nutrition,
R A Franklin, and
P J Southgate, and
A J Coleman
December 1975,
Journal of pharmaceutical sciences,
R A Franklin, and
P J Southgate, and
A J Coleman
July 1986,
European journal of anaesthesiology,
R A Franklin, and
P J Southgate, and
A J Coleman
May 1986,
International journal of clinical pharmacology, therapy, and toxicology,
