-transparent.png){kind=logo}
A new technique enabling repetitive sampling of cerebrospinal fluid (CSF) in unanesthetized rhesus monkeys was developed to study the pharmacokinetics of methotrexate (MTX) in the CSF. CSF and plasma MTX levels were monitored following intraventricular and intravenous MTX administration. CSF and plasma MTX disappearance curves in the monkey were virtually identical to curves generated in humans, suggesting that the mechanisms of transport between the CSF and plasma compartments are similar in both species. These observations validate this experimental primate model and indicate its potential application to the pharmacological study of CNS chemotherapeutic agents in man.
Related Publications
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
May 1992,
The Journal of comparative neurology,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
May 2018,
Journal of pharmaceutical sciences,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
December 1978,
Cancer treatment reports,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
July 1996,
Neurochemical research,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
February 1986,
The Journal of pharmacology and experimental therapeutics,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
March 1978,
Cancer research,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
November 1967,
Surgery, gynecology & obstetrics,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
March 1980,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
January 1980,
Clinical bulletin,
D G Poplack, and
W A Bleyer, and
J H Wood, and
M Kostolich, and
J L Savitch, and
A K Ommaya
January 1984,
Cancer drug delivery,
