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The ability of various gangliosides to inhibit the cytotoxic activity of natural killers (NK-cells) from Syrian hamsters towards human lymphoma MOLT-4 cells was studied. The inhibitory effect was found to depend on the structure and concentration of the gangliosides. At concentrations corresponding to those in the blood of tumour-bearing hosts, SiaLacCer and Sia2LacCer inhibited the NK-activity. A significant inhibition was also found for (NeuAc)2GgOse3Cer, whereas NeuGcGgOse3Cer and NeuAcGgOse4Cer were practically inactive. Previously it was shown that Sia2LacCer which is either absent or very low in normal blood, is produced by a number of tumours and that tumour cells "shed" considerable amounts of gangliosides. On this ground, it was proposed that elevated concentrations of SiaLacCer and Sia2LacCer in the blood of tumour-bearing animals may inhibit the NK-activity and thus contribute to the "escape" of tumour cells from host immune surveillance.
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
April 1986,
Biulleten' eksperimental'noi biologii i meditsiny,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
January 1987,
Doklady Akademii nauk SSSR,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
September 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
January 1990,
Doklady Akademii nauk SSSR,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
February 1988,
Biulleten' eksperimental'noi biologii i meditsiny,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
May 1990,
FEBS letters,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
October 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
March 1980,
British journal of cancer,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
January 1988,
Voprosy virusologii,
E V Diatlovitskaia, and
E V Kliuchareva, and
V A Matveeva, and
E V Sinitsyna, and
A Sh Akhmed-Zade
January 1972,
Voprosy onkologii,
