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Seventy-four adult patients with acute leukemia in relapse were studied. They received high-dose intravenous boluses of cytosine arabinoside (Ara-C) according to the following schedules: 3 g/m2 over 2 hours, every 12 hours for 4 to 12 consecutive doses, or a continuous infusion over 5 days at 200, 400, or 800 mg/m2/day. The patients' ages ranged from 16 to 68 years (median, 35). Subacute pulmonary failure attributable to Ara-C was observed in 16 of 72 evaluable patients (22%) and appeared 2 to 21 days (median, 6) after the first dose. None of the 28 patients who received up to six doses experienced any toxicity. With repeated courses or more than six doses in the first course there was a sharp increase in the incidence of toxicity. Thus, subacute pulmonary failure developed in 6 of 24 patients who received 9 doses and 6 of 19 patients who received 12 doses. The increase in toxicity with increasing number of doses is significant (P = 0.03). This suggests that the high-dose Ara-C regimen should be used with awareness of possible drug-induced pulmonary toxicity.
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
March 1990,
Cancer,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
January 1988,
Medical oncology and tumor pharmacotherapy,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
April 1996,
Leukemia,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
May 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
May 1988,
Leukemia,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
February 1983,
Cancer,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
June 1984,
Cancer,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
June 1985,
Seminars in oncology,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
June 1985,
Seminars in oncology,
B S Andersson, and
B M Cogan, and
M J Keating, and
E H Estey, and
K B McCredie, and
E J Freireich
February 1981,
The American journal of medicine,
