Etiology and prevention of topical cardiac hypothermia-induced phrenic nerve injury and left lower lobe atelectasis during cardiac surgery. 1985

W E Wheeler, and L J Rubis, and C W Jones, and J D Harrah

Left hemidiaphragm elevation is frequently noted following cardiac surgery employing topical hypothermia. We speculate that contact of the left phrenic nerve with ice causes nerve injury, resulting in left hemidiaphragm paresis or paralysis and left lower lobe atelectasis. Left diaphragm elevation was noted on postoperative chest x-ray examination of 36 of 60 (60 percent) consecutive patients in whom topical cooling of the heart with a cold slush solution was administered prior to use of a cardiac insulation pad (CIP, Shiley Laboratories, Irvine, California). Following the use of the CIP in a similar group of 60 consecutive patients, only five (8 percent) showed evidence of diaphragmatic elevation. The difference in the incidence of diaphragmatic elevation between these two groups is statistically significant (p less than 0.001). A comparison of postoperative left lower lobe atelectasis prior to the use of the CIP was also statistically significant (p less than 0.001). There was no significant difference in the aortic cross-clamp time or the volume of intraaortic cardioplegia used in these two groups. The use of topical cardiac hypothermia has been shown to protect the myocardium. Phrenic nerve injury secondary to the use of ice in this method has been documented. The use of a cold solution without ice chips or slush, or the insertion of a CIP prior to the use of topical cardiac hypothermia (when ice chips or slush are used) decreases the exposure of the phrenic nerve to cold injury and decreases the incidence of paresis of the left diaphragm and resultant atelectasis.

UI MeSH Term Description Entries
D007036 Hypothermia, Induced Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries. Induced Hypothermia,Mild Hypothermia, Induced,Moderate Hypothermia, Induced,Targeted Temperature Management,Therapeutic Hypothermia,Hypothermia, Therapeutic,Induced Mild Hypothermia,Induced Mild Hypothermias,Induced Moderate Hypothermia,Induced Moderate Hypothermias,Mild Hypothermias, Induced,Moderate Hypothermias, Induced,Targeted Temperature Managements
D010791 Phrenic Nerve The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm. Nerve, Phrenic,Nerves, Phrenic,Phrenic Nerves
D003964 Diaphragm The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION. Respiratory Diaphragm,Diaphragm, Respiratory,Diaphragms,Diaphragms, Respiratory,Respiratory Diaphragms
D006324 Heart Arrest, Induced A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate). Cardiac Arrest, Induced,Cardioplegia,Induced Cardiac Arrest,Induced Heart Arrest,Cardioplegias
D006348 Cardiac Surgical Procedures Surgery performed on the heart. Cardiac Surgical Procedure,Heart Surgical Procedure,Heart Surgical Procedures,Procedure, Cardiac Surgical,Procedure, Heart Surgical,Procedures, Cardiac Surgical,Procedures, Heart Surgical,Surgical Procedure, Cardiac,Surgical Procedure, Heart,Surgical Procedures, Cardiac,Surgical Procedures, Heart
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001261 Pulmonary Atelectasis Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors. Atelectasis, Congestive,Lung Collapse,Atelectasis,Compression Atelectasis,Compression Pulmonary Atelectasis,Congestive Atelectasis,Congestive Pulmonary Atelectasis,Contraction Pulmonary Atelectasis,Postoperative Pulmonary Atelectasis,Resorption Atelectasis,Resorption Pulmonary Atelectasis,Atelectases,Atelectases, Compression,Atelectases, Compression Pulmonary,Atelectases, Congestive,Atelectases, Congestive Pulmonary,Atelectases, Contraction Pulmonary,Atelectases, Postoperative Pulmonary,Atelectases, Pulmonary,Atelectases, Resorption,Atelectases, Resorption Pulmonary,Atelectasis, Compression,Atelectasis, Compression Pulmonary,Atelectasis, Congestive Pulmonary,Atelectasis, Contraction Pulmonary,Atelectasis, Postoperative Pulmonary,Atelectasis, Pulmonary,Atelectasis, Resorption,Atelectasis, Resorption Pulmonary,Collapse, Lung,Compression Atelectases,Compression Pulmonary Atelectases,Congestive Atelectases,Congestive Pulmonary Atelectases,Contraction Pulmonary Atelectases,Postoperative Pulmonary Atelectases,Pulmonary Atelectases,Pulmonary Atelectases, Compression,Pulmonary Atelectases, Congestive,Pulmonary Atelectases, Contraction,Pulmonary Atelectases, Postoperative,Pulmonary Atelectases, Resorption,Pulmonary Atelectasis, Compression,Pulmonary Atelectasis, Congestive,Pulmonary Atelectasis, Contraction,Pulmonary Atelectasis, Postoperative,Pulmonary Atelectasis, Resorption,Resorption Atelectases,Resorption Pulmonary Atelectases

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