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To evaluate the efficacy of surveillance colonoscopy with biopsy for the detection of high-grade dysplasia (HGD) or colonic carcinoma in patients with chronic ulcerative colitis, we undertook a retrospective review of 248 patients who underwent 370 examinations (mean duration of disease 12 yr). High-grade dysplasia or carcinoma was found in 24 examinations in 16 patients, with a mean duration of disease of 16 yr. There were 15 patients with HGD. Nine patients had HGD alone, 6 had HGD and carcinoma, and 1 had carcinoma without HGD. The overall incidence of HGD was 6%. Dysplasia-associated lesions or mass were the most consistent indicators of carcinoma, the combination being present in four instances. Of the 7 patients with cancer, 6 were recognized by colonoscopy, and 1 patient with negative visual endoscopic findings was discovered using surveillance biopsies. The conclusions of this study are that dysplasia is a reliable histopathologic marker and correlates with the presence of cancer in chronic ulcerative colitis; the absence of dysplasia correlates with the absence of cancer. The presence of dysplasia-associated lesions or mass with HGD is the strongest indication for operation. This study supports the use of surveillance colonoscopy in managing high-risk ulcerative colitis patients.
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
September 2000,
Deutsche medizinische Wochenschrift (1946),
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
February 1970,
Ugeskrift for laeger,
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
January 1995,
European journal of cancer (Oxford, England : 1990),
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
January 1964,
Archives of internal medicine,
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
July 2009,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
July 2016,
Inflammatory bowel diseases,
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
December 2014,
United European gastroenterology journal,
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
November 1982,
Orvosi hetilap,
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
February 1977,
Journal of the Indian Medical Association,
E Rosenstock, and
R G Farmer, and
R Petras, and
M V Sivak, and
G B Rankin, and
B H Sullivan
May 1967,
Lakartidningen,
