BIOMAT Database Logo BIOMAT Database Logo

Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. 1985

R F Mortensen, and P T Le, and B A Taylor

Recombinant inbred strains were used to demonstrate the existence of a major locus on chromosome 1, designated Sap, which controls the endogenous concentration of the mouse acute phase reactant, serum amyloid P-component (SAP). Levels of SAP were associated with alleles at the Ly-9 locus in two sets of RI strains: BXD (C57BL/6J X DBA/2) and BXH (C57BL/6J X C3H/HeJ). Low endogenous levels of SAP were present in the C57BL/6J progenitor strain and in most of the RI strains which inherited the Ly-9b allele. High levels of SAP were present in the DBA/2J and C3H/HeJ progenitors and in most of the RI strains which inherited the Ly-9a allele. In the BXD strains 91% of the genetic variation of SAP levels was accounted for by segregation at the Ly-9 locus while an additional 9% was attributed to genetic factors unlinked to Ly-9. In the BXH strains the percentage of genetic variation accounted for by Ly-9 segregation was reduced to 46%, while 54% was accounted for by other genetic factors. Because of background genetic variation it was not possible to detect any crossovers between Sap and Ly-9. However, in the BXD strains the linkage between Sap and Ly-9 appears to be quite close. The B6.C-H-25c congenic strain, which carries a segment of BALB/c chromosome 1 including the minor histocompatibility locus H-25 on a C57BL/6By background, had the same endogenous SAP level as the BALB/c donor strain.

UI MeSH Term Description Entries
D008040 Genetic Linkage The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. Genetic Linkage Analysis,Linkage, Genetic,Analyses, Genetic Linkage,Analysis, Genetic Linkage,Genetic Linkage Analyses,Linkage Analyses, Genetic,Linkage Analysis, Genetic
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000682 Amyloid A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease. Amyloid Fibril,Amyloid Fibrils,Amyloid Substance,Fibril, Amyloid,Fibrils, Amyloid,Substance, Amyloid
D000683 Serum Amyloid P-Component Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE. Amyloid P Component,Amyloid P-Component, Serum,P Component, Amyloid,P-Component, Serum Amyloid,Serum Amyloid P Component
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

R F Mortensen, and P T Le, and B A Taylor
Binding of serum amyloid P-component (SAP) by amyloid fibrils.
November 1979, Clinical and experimental immunology,
R F Mortensen, and P T Le, and B A Taylor
Isolation of serum amyloid P-component (protein SAP) in the mouse.
July 1979, Immunology,
R F Mortensen, and P T Le, and B A Taylor
Molecular genetics of mouse serum amyloid P component (SAP): cloning and gene mapping.
January 1988, Immunogenetics,
R F Mortensen, and P T Le, and B A Taylor
Nephelometric measurement of human serum amyloid P component (SAP).
November 1983, The Journal of laboratory and clinical medicine,
R F Mortensen, and P T Le, and B A Taylor
Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels.
February 2017, Biochemistry,
R F Mortensen, and P T Le, and B A Taylor
Regulation of the antibody response by the acute phase reactant: mouse serum amyloid P-component (SAP).
May 1987, Cellular immunology,
R F Mortensen, and P T Le, and B A Taylor
Purification of human serum amyloid P component (SAP) by calcium affinity chromatography.
December 1989, Biotechnology and applied biochemistry,
R F Mortensen, and P T Le, and B A Taylor
Enhanced interleukin 1 (IL-1) production mediated by mouse serum amyloid P component.
July 1985, Cellular immunology,
R F Mortensen, and P T Le, and B A Taylor
The role of serum amyloid P (SAP) component in Alzheimer's disease.
January 1996, Neurobiology (Budapest, Hungary),
R F Mortensen, and P T Le, and B A Taylor
Receptor-mediated binding of the acute-phase reactant mouse serum amyloid P-component (SAP) to macrophages.
December 1988, Cellular immunology,
Copied contents to your clipboard!