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Problems and results of trace analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 2,4,5-trichlorophenoxyacetic acid and its esters. 1985

R D Weeren, and J Asshauer

Quantitative analysis of tetrachlorodibenzo-p-dioxins (TCDDs) has gained increasing importance in the public domain. The analytical problem is complex because of the large number of interfering isomers and the extremely low limit of determination enforced by legislation. DAPA elaborated a procedure based on the latest published methods and on the existing experience of the collaborators. This procedure involves preseparation of the original sample on a silica column and cleanup by liquid chromatography (LC) on alumina. Alkaline saponification of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) esters seems to create artificial dioxins in the organic extract. Final determination is performed by capillary gas chromatography (GC)-low resolution mass spectrometry (MS). Final international collaborative work was carried out on 4 samples. Results were reported by 13 of 20 laboratories. Mean values ranged from 3.5 to 8.7 micrograms/kg. The interlaboratory reproducibilities ranged from 3.4 to 8.2 micrograms/kg (about 100% of the mean value).

UI MeSH Term Description Entries
D008401 Gas Chromatography-Mass Spectrometry A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds. Chromatography, Gas-Liquid-Mass Spectrometry,Chromatography, Gas-Mass Spectrometry,GCMS,Spectrometry, Mass-Gas Chromatography,Spectrum Analysis, Mass-Gas Chromatography,Gas-Liquid Chromatography-Mass Spectrometry,Mass Spectrometry-Gas Chromatography,Chromatography, Gas Liquid Mass Spectrometry,Chromatography, Gas Mass Spectrometry,Chromatography, Mass Spectrometry-Gas,Chromatography-Mass Spectrometry, Gas,Chromatography-Mass Spectrometry, Gas-Liquid,Gas Chromatography Mass Spectrometry,Gas Liquid Chromatography Mass Spectrometry,Mass Spectrometry Gas Chromatography,Spectrometries, Mass-Gas Chromatography,Spectrometry, Gas Chromatography-Mass,Spectrometry, Gas-Liquid Chromatography-Mass,Spectrometry, Mass Gas Chromatography,Spectrometry-Gas Chromatography, Mass,Spectrum Analysis, Mass Gas Chromatography
D002853 Chromatography, Liquid Chromatographic techniques in which the mobile phase is a liquid. Liquid Chromatography
D004147 Dioxins A family of compounds that contain the 1,4-dioxin structure. Many specific dioxin derivatives are listed as CARCINOGENS; TERATOGENS; or MUTAGENS. Dioxin
D000072317 Polychlorinated Dibenzodioxins Dibenzodioxin derivatives that contain multiple chloride atoms bound to the benzene ring structures. TCDD,Tetrachlorodibenzodioxin,2,3,7,8-Tetrachlorodibenzo-p-dioxin,Chlorinated Dibenzo-p-dioxins,Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-,PCDD,Polychlorinated Dibenzo-p-dioxins,Polychlorinated Dibenzodioxin,Polychlorodibenzo-4-dioxin,Polychlorodibenzo-p-dioxin,Tetrachlorodibenzo-p-dioxin,Chlorinated Dibenzo p dioxins,Dibenzo-p-dioxins, Chlorinated,Dibenzo-p-dioxins, Polychlorinated,Dibenzodioxin, Polychlorinated,Dibenzodioxins, Polychlorinated,Polychlorinated Dibenzo p dioxins,Polychlorodibenzo 4 dioxin,Polychlorodibenzo p dioxin,Tetrachlorodibenzo p dioxin
D015085 2,4,5-Trichlorophenoxyacetic Acid An herbicide with strong irritant properties. Use of this compound on rice fields, orchards, sugarcane, rangeland, and other noncrop sites was terminated by the EPA in 1985. (From Merck Index, 11th ed) 2,4,5-T

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