Effects of formaldehyde and acetaldehyde inhalation on rat pulmonary mechanics. 1985

P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva

Two groups of 12 male Wistar rats received either 243 ppm of acetaldehyde or 5.7 ppm of formaldehyde for 8 h a day, 5 days a week during 5 weeks. These levels represent three times the threshold limit values (TLV) for these substances in Brazilian legislation. The animals were evaluated by pulmonary function tests before and after exposure to the pollutants. The data obtained from these rats were compared with those of 12 controls, housed in identical conditions for the same length of time but breathing normal air. The results showed an increase of the functional residual capacity, residual volume, total lung capacity and respiratory frequency in the rats exposed to acetaldehyde atmosphere. The animals exposed to formaldehyde did not present pulmonary function alterations when compared with the controls. The damage caused by acetaldehyde to the peripheral regions of the lung parenchyma, affecting small airways or altering pulmonary elastic properties, is discussed. It is suggested that the Brazilian TLV for acetaldehyde (78 ppm) is not as safe as that for formaldehyde (1.6 ppm).

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D008452 Maximum Allowable Concentration The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed) Maximum Permissible Exposure Level,MPEL,Maximum Permissible Exposure Concentration,Allowable Concentration, Maximum,Allowable Concentrations, Maximum,Concentration, Maximum Allowable,Concentrations, Maximum Allowable,MPELs,Maximum Allowable Concentrations
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D012129 Respiratory Function Tests Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc. Lung Function Tests,Pulmonary Function Tests,Function Test, Pulmonary,Function Tests, Pulmonary,Pulmonary Function Test,Test, Pulmonary Function,Tests, Pulmonary Function,Function Test, Lung,Function Test, Respiratory,Function Tests, Lung,Function Tests, Respiratory,Lung Function Test,Respiratory Function Test,Test, Lung Function,Test, Respiratory Function,Tests, Lung Function,Tests, Respiratory Function
D005557 Formaldehyde A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) Formalin,Formol,Methanal,Oxomethane
D000079 Acetaldehyde A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis. Ethanal
D000393 Air Pollutants Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or materials. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS. Air Pollutant,Air Pollutants, Environmental,Environmental Air Pollutants,Environmental Pollutants, Air,Air Environmental Pollutants,Pollutant, Air,Pollutants, Air,Pollutants, Air Environmental,Pollutants, Environmental Air
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
January 1988, Intensive care medicine,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
June 2005, Biomedical and environmental sciences : BES,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
April 2021, American journal of physiology. Heart and circulatory physiology,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
October 2018, Toxicology and industrial health,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
February 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
September 1986, Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
March 2010, Toxicology and industrial health,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
June 1981, Metabolism: clinical and experimental,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
March 1974, Cardiovascular research,
P H Saldiva, and M P do Rio Caldeira, and E Massad, and D F Calheiros, and L M Cardoso, and G M Böhm, and C D Saldiva
January 1982, Archives of environmental health,
Copied contents to your clipboard!