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In a series of 1,389 cases of laryngeal cancer, multiple primary malignancies were found in 138 cases, 9.94 per cent. In these 138 patients, the most frequent sites of occurrence were the stomach and lung. Nine cases of triplicated malignancies and two cases of quadruplicate malignancies were found, and all died from the cancers. So-called radiation induced cancers were found in the 13 cases, showing a tendency toward field carcinogenesis or multicentric carcinogenesis. In 76 per cent of multiple primary tumours, the second or third tumour was the cause of death. The importance of inquiry regarding other malignancies in treatment and follow-up of laryngeal cancer was discussed. To obtain better survival of laryngeal cancer patients, early diagnosis and early treatment of the second primary tumours is essential.
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
August 1986,
The Journal of laryngology and otology,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
February 1988,
Singapore medical journal,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
January 1992,
Acta oto-rhino-laryngologica Belgica,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
February 1986,
International journal of oral and maxillofacial surgery,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
January 1990,
Otolaryngologia polska = The Polish otolaryngology,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
September 1993,
Pathology, research and practice,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
June 1990,
Japanese journal of clinical oncology,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
March 1986,
The British journal of clinical practice,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
August 2005,
Endoscopy,
H Miyahara, and
K Yoshino, and
K Umatani, and
T Sato
January 1966,
Srpski arhiv za celokupno lekarstvo,
