The result of the group study on adjuvant chemotherapy with HD-MTX, ADR and CPM for 25 cases of osteosarcomas is as follows: Overall survival at three and a half years is 58.4% and the disease-free survival is 40%. In our clinics, 66 cases of osteosarcomas were treated by the radical surgery from 1955. Overall survival of these cases at five years was 49%. Overall survival between 1955 and 1974 was 43% and that from 1975, the year when ADR was introduced, to date was 55%. The data of the group study of soft tissue sarcoma sponsored by Ministry of Health and Welfare show that in 318 cases of soft tissue sarcomas of extremities, the recurrence rate during the period between 1962 and 1976 is 52%, metastasis rate 69%, and overall survival at 5 years 42%. From 1972 to 1983, in 414 cases treated by the orthopaedic clinics of the same group the recurrence rate become as low as 23% metastasis rate 45% and overall survival at 5 years 56%. In our clinics, 89 patients with soft tissue sarcomas were treated by the curative wide resection and the recurrence rate is 12%, metastasis rate 25%, and overall survival at 5 years 78%. In this series, in 80% of cases limb salvage is succeeded.