Bicycle ergometry was conducted in conjunction with the consecutive administration of the placebo, 80 mg anaprylin, 30 mg corinfar, and 80 mg anaprylin + 30 mg corinfar in patients with 2nd--4th class angina of effort. Both anaprylin and corinfar significantly raised patients' physical stress tolerance, increased the total amount of work done, and reduced the magnitude of St depression during exercise. Combined use of anaprylin and corinfar produced the greatest rise in physical stress tolerance in more favorable hemodynamic conditions. Bicycle ergometry in conjunction with anaprylin and corinfar can supply additional functional information on angina pectoris and its pathogenetic mechanisms.