-transparent.png){kind=logo}
We investigated antipyrine clearance and urinary excretion of 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and nor-antipyrine in rats after 70% partial hepatectomy. Antipyrine clearance recovered more slowly than liver weight but after 240 h both liver weight and antipyrine clearance had reached control values. During hepatic regeneration conversion of antipyrine to the three major metabolites was reduced, conversion to 3-hydroxymethylantipyrine being reduced more than conversion to the other metabolites. Antipyrine clearance was closely correlated to liver weight (r = 0.81), indicating a close relation between the functional hepatic mass and the liver weight during hepatic regeneration.
H E Poulsen, and
H Pilsgaard
June 1980,
Life sciences,
H E Poulsen, and
H Pilsgaard
September 1990,
The Journal of sports medicine and physical fitness,
H E Poulsen, and
H Pilsgaard
January 1951,
Doklady Akademii nauk SSSR,
H E Poulsen, and
H Pilsgaard
January 1986,
The International journal of biochemistry,
H E Poulsen, and
H Pilsgaard
January 1983,
Drug metabolism and disposition: the biological fate of chemicals,
H E Poulsen, and
H Pilsgaard
September 1987,
Biochemical pharmacology,
H E Poulsen, and
H Pilsgaard
August 1972,
Biochimica et biophysica acta,
H E Poulsen, and
H Pilsgaard
September 1980,
Clinical pharmacology and therapeutics,
H E Poulsen, and
H Pilsgaard
January 1986,
Farmakologiia i toksikologiia,
H E Poulsen, and
H Pilsgaard
January 1970,
Acta hepato-splenologica,
