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The authors discuss the results of studies on the choice of highly-reproducible and sufficiently informative methods of 9-antigen standardization in a new chemical vaccine against cholera (cholerogen-toxoid); materials were collected under conditions of controlled epidemilogical trial. Titration of O-antigen in industrial batches of the preparation with the aid of precipitation in gel against standard O-cholera serum could be used for its standardization. Quantitative limits of O-antigen responsible for the formation of vibration (antimicrobial) antibodies in the persons vaccinated were found by studying the immunogenicity and reactogenicity of a number of cholerogen-toxoid batches contrast by O-antigen content described by means of the precipitation test.
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
November 1975,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
April 1984,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
May 1976,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
May 1972,
The Journal of infectious diseases,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
August 1974,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
July 1978,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
June 1970,
Japanese journal of medical science & biology,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
October 1977,
Nature,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
November 1979,
Infection and immunity,
A A Sumarokov, and
M N Dzhaperidze, and
N R Ivanov, and
L T Karaeva, and
A A Popov
December 1974,
Japanese journal of medical science & biology,
