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Unscheduled DNA synthesis induced by 254-nm UV radiation in chicken embryo fibroblasts was examined for 24 h following irradiation, while cells were kept in the dark. The effect on this repair process of a 2-4 h exposure to photoreactivating light immediately after UV was studied. Initial [3H]thymidine incorporation in the light-treated cells was only slightly different from that in cells not exposed to light, but a distinct difference in rate and cumulative amount of unscheduled DNA synthesis was seen several hours after irradiation. By varying the UV dose and the time allowed for photoreactivation, the amount of dimers (determined as sites sensitive to a M. luteus UV-endonuclease) and non-dimers could be changed. The results of these experiments suggest that excision repair of dimers, rather than non-dimer products, is responsible for the unscheduled DNA synthesis seen after UV irradiation.
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March 1980,
Mutation research,
L Roza, and
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October 1982,
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September 1985,
Mutation research,
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February 1973,
Archives internationales de physiologie et de biochimie,
L Roza, and
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July 1991,
The Journal of investigative dermatology,
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March 1978,
Radiation and environmental biophysics,
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December 1976,
Radiation research,
L Roza, and
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June 1981,
Mutation research,
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F Berends
June 1984,
Mechanisms of ageing and development,
L Roza, and
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September 1975,
Radiation research,
